Recombinant human CGREF1 protein
CGREF1, also known as cell growth regulator with EF-hand domain 1, is a secreted calcium ion binding protein. This protein contains two EF-hand domains and both EF-hands are required for function. It is probably digested extracellularly by an unknown serine protease generating extremely hydrophobic bioactive peptides. It mediates cell-cell adhesion in a calcium-dependent manner. In addition, CGREF1 is able to inhibit growth in several cell lines. Recombinant human CGREF1 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
Cell growth regulator with EF-hand domain 1, Cell growth regulator with EF-hand domain 1, CGR11
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
32.3 kDa (305aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Dolcino M. et al. (2012) Clin Dev Immunol. 2012:198956.; ; Madden SL. D.H. et al. (1996) Cancer Res. 56:5384-5390.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4)
Scientific Category
Cell Cycle
NCBI Accession Number
AAH34764
Uniprot Accession Number
Q99674
Species
Human
AA Sequence
Frequently Asked Questions
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