Recombinant mouse GDF-15 protein
Growth/differentiation factor 15, also known as GDF15, is a member of the TGF superfamily. It has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes. They are synthesized as precursor molecules that are processed at a dibasic cleavage site to release C-terminal domains containing a characteristic motif of 7 conserved cysteines in the mature protein. Recombinant mouse GDF15 fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Growth/differentiation factor 15 precursor, Growth/differentiation factor 15 precursor, MIC-1, NAG-1, SBF
Expression System
E.coli
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
14.9 kDa (138aa)
Additionnal Information
References & Citations
Zimmers TA, Jin X, et al. (2005) . Shock. 23 (6) :543-8.; ; Hsiao EC, Koniaris LG, et al. (2000) . Mol Cell Biol. 20 (10) :3742-51.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Scientific Category
Hormones & Cytokines
NCBI Accession Number
NP_035949.2
Uniprot Accession Number
Q9Z0J7
Species
Mouse
AA Sequence
SAHAHPR DSCPLGPGRC CHLETVQATL EDLGWSDWVL SPRQLQLSMC VGECPHLYRS ANTHAQIKAR LHGLQPDKVP APCCVPSSYT PVVLMHRTDS GVSLQTYDDL VARGCHCA
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