Lomeguatrib
Lomeguatrib is a O6-methylguanine-DNA methyltransferase (MGMT) inhibitor, with IC50s of 9 nM in cell-free assay and ～6 nM in MCF-7 cells.
Product Specifications
CAS Number
[192441-08-0]
Product Name Alternative
PaTrin-2
UNSPSC
12352005
Hazard Statement
H302
Target
DNA Methyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Lomeguatrib.html
Purity
99.77
Solubility
DMSO : ≥ 56 mg/mL
Smiles
NC1=NC(OCC2=CC(Br)=CS2)=C3N=CNC3=N1
Molecular Formula
C10H8BrN5OS
Molecular Weight
326.17
Precautions
H302
References & Citations
[1]Reinhard J, et al. Monosaccharide-linked inhibitors of O (6) -methylguanine-DNA methyltransferase (MGMT) : synthesis, molecular modeling, and structure-activity relationships. J Med Chem. 2001 Nov 22;44 (24) :4050-61.|[2]Clemons M, et al. O6- (4-bromothenyl) guanine reverses temozolomide resistance in human breast tumour MCF-7 cells and xenografts. Br J Cancer. 2005 Nov 14;93 (10) :1152-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
MGMT
Available Sizes
Curated Selection
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