Recombinant human DPPA5/ESG1 protein
Developmental pluripotency-associated 5 proteins, also known as DPPA5, is a 116 amino acid protein that localizes to the cytoplasm and contains one KH domain. Expressed in embryonic germ (EG), primordial germ (PG) and embryonic stem (ES) cells, DPPA5 plays an important role in the maintenance of ES cell pluripotency and may be necessary for proper embryogenesis. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Recombinant human DPPA5 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Developmental pluripotency-associated 5 proteins, Developmental pluripotency-associated 5 proteins, ESG1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
15.9 kDa (139aa)
Additionnal Information
References & Citations
Kim S K., et al. (2005) Stem Cells. 23: 458-462.; ; Pirre A., et al. (2007) Genomics. 90: 583-594.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Phosphate buffer (pH 8.0) containing 10% glycerol
Scientific Category
Stem cell
NCBI Accession Number
NP_001020461
Uniprot Accession Number
A6NC42
Species
Human
AA Sequence
MGTLPAR RHIPPWVKVP EDLKDPEVFQ VQTRLLKAIF GPDGSRIPYIEQVSKAMLEL KALESSDLTE VVVYGSYLYK LRTKWMLQSM AEWHRQRQER GMLKLAEAMN ALELGPWMK
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