Recombinant human PAX8 protein
Paired box protein Pax-8 isoform PAX8E, also known as PAX8, is expressed in the developing and adult thyroid, the developing secretory system and at lower levels, in the adult kidney. PAX8complexes with TTF-1 and TTF-2 to induce thyroid follicular cell differentiation and thyroid hormone biosynthesis by regulating the expression of sodium iodide symporter (NIS), thyroid peroxidase (TPO), thyroglobulin (TG) and the thyrotropin receptor (TSHR) . Defects in PAX8 are the cause of congenital hypothyroidism non-goitrous type 2 (CHNG2) . Recombinant human PAX8 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Paired box protein Pax-8 isoform PAX8E, Paired box protein Pax-8 isoform PAX8E, paired box 8
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
33.4 kDa (310aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Paters H., et al. (1998) Eur J Oral Sci. 106: 38-43.; ; Poleev A., et al. (1995) Eur J Biochem. 228: 899-911.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 20% glycerol , 1mM DTT
Scientific Category
Neuroscience
NCBI Accession Number
NP_054698.1
Uniprot Accession Number
Q06710
Species
Human
AA Sequence
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