Recombinant mouse BMP-14/GDF-5 protein

Growth/differentiation factor 5 precursor, also known as GDF5, is a member of the TGF superfamily. GDF5 has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. GDF5mutations have been identified in mice with the mutation brachypodism (bp), a mutation which affects the length and number of bones in limbs. Recombinant mouse GDF5 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Growth differentiation factor 5, CDMP-1, Cartilage-derived morphogenetic protein 1, BRP, BP, Bone morphogenetic protein 14, BMP-14

Expression System

E.coli

Antigen Species

Mouse

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

16 kDa (143aa)

Additionnal Information

Growth/differentiation factor 5 precursor, Growth differentiation factor 5, GDF5, CDMP-1, Cartilage-derived morphogenetic protein 1, BRP, BP, Bone morphogenetic protein 14, BMP-14, BMP14, BMP 14, ATGP2894-10 µg, ATGP2894-20 µg, ATGP2894-50 µg, ATGP2894-100 µg, ATGP2894-250 µg, ATGP2894-500 µg, ATGP2894-1 mg, ATGP2894-010, ATGP2894-020, ATGP2894-050, ATGP2894-100, ATGP2894-250, ATGP2894-500, ATGP2894-01M

References & Citations

Katayama R., et al. (2004) Rheumatology. 43: 980-985.; ; Kwong F N., et al. (2008) J Orthop Res. 27: 752-757.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Scientific Category

Hormones & Cytokines

NCBI Accession Number

NP_032135

Uniprot Accession Number

P43027

Species

Mouse

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSAPLANRQ GKRPSKNLKA RCSRKALHVN FKDMGWDDWI IAPLEYEAFH CEGLCEFPLR SHLEPTNHAV IQTLMNSMDP ESTPPTCCVP TRLSPISILF IDSANNVVYK QYEDMVVESC GCR