Recombinant mouse BMP-14/GDF-5 protein
Growth/differentiation factor 5 precursor, also known as GDF5, is a member of the TGF superfamily. GDF5 has been shown to induce activation of plasminogen activator, thereby inducing angiogenesis. It is predominantly expressed in long bones during fetal embryonic development and is involved in bone formation. GDF5mutations have been identified in mice with the mutation brachypodism (bp), a mutation which affects the length and number of bones in limbs. Recombinant mouse GDF5 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Growth differentiation factor 5, CDMP-1, Cartilage-derived morphogenetic protein 1, BRP, BP, Bone morphogenetic protein 14, BMP-14
Expression System
E.coli
Antigen Species
Mouse
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
16 kDa (143aa)
Additionnal Information
References & Citations
Katayama R., et al. (2004) Rheumatology. 43: 980-985.; ; Kwong F N., et al. (2008) J Orthop Res. 27: 752-757.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol
Scientific Category
Hormones & Cytokines
NCBI Accession Number
NP_032135
Uniprot Accession Number
P43027
Species
Mouse
AA Sequence
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