Recombinant human ELP4 protein

ELP4 is a component of the six subunit elongator complex, a histone acetyltransferase complex that associates directly with RNA polymerase II during transcriptional elongation. The human gene can partially complement sensitivity phenotypes of yeast ELP4 deletion mutants. Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only one has been determined. Recombinant human ELP4 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Elongator complex protein 4, C11orf19, dJ68P15A.1, PAX6NEB, PAXNEB

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 80% by SDS-PAGE

Molecular Weight

49 kDa (447aa)

Additionnal Information

ELP4, Elongator complex protein 4, C11orf19, dJ68P15A.1, PAX6NEB, PAXNEB, ATGP2846-10 µg, ATGP2846-20 µg, ATGP2846-50 µg, ATGP2846-100 µg, ATGP2846-250 µg, ATGP2846-500 µg, ATGP2846-1 mg, ATGP2846-10, ATGP2846-20, ATGP2846-50, ATGP2846-100, ATGP2846-250, ATGP2846-500, ATGP2846-1

References & Citations

Strug, L.J., et al. (2009) Eur. J. Hum. Genet. 17 (9), 1171-1181.; ; Miele, A., et al. (2007) J. Cell. Biochem. 102 (1), 136-148.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol

Scientific Category

Epigenomics (Transcription & Translation)

NCBI Accession Number

NP_061913

Uniprot Accession Number

Q96EB1

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSMAAVATC GSVAASTGSA VATASKSNVT SFQRRGPRAS VTNDSGPRLV SIAGTRPSVR NGQLLVSTGL PALDQLLGGG LAVGTVLLIE EDKYNIYSPL LFKYFLAEGI VNGHTLLVAS AKEDPANILQ ELPAPLLDDK CKKEFDEDVY NHKTPESNIK MKIAWRYQLL PKMEIGPVSS SRFGHYYDAS KRMPQELIEA SNWHGFFLPE KISSTLKVEP CSLTPGYTKL LQFIQNIIYE EGFDGSNPQK KQRNILRIGI QNLGSPLWGD DICCAENGGN SHSLTKFLYV LRGLLRTSLS ACIITMPTHL IQNKAIIARV TTLSDVVVGL ESFIGSERET NPLYKDYHGL IHIRQIPRLN NLICDESDVK DLAFKLKRKL FTIERLHLPP DLSDTVSRSS KMDLAESAKR LGPGCGMMAG GKKHLDF