Recombinant human KLF12 protein
KLF12, as known as Krueppel-like factor 12, is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene. cers. Recombinant human KLF12 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Krueppel-like factor 12, AP-2rep, AP2REP, HSPC122
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
46.6 kDa (425aa)
Additionnal Information
References & Citations
Roth C. et al. (1996) Genomics. 63:384-390.; ; Schuierer M. et al. (2001) J Biol Chem. 276:27944-27949.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M Urea
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_009180
Uniprot Accession Number
Q9Y4X4
Species
Human
AA Sequence
Frequently Asked Questions
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