Recombinant human NCS1 protein
NCS1 is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. This protein regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. It is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene. Recombinant human NCS1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Neuronal calcium sensor 1 isoform 1, FLuP, FREQ
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
24.3. kDa (213aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Nakamura T.Y., et al (2001) . Proc. Natl. Acad. Sci. u.S.A. 98:12808-12813; ; Bahi N., et al (2003) . Hum. Mol. Genet. 12:1415-1425
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 30% glycerol, 1mM DTT
Scientific Category
Neuroscience
NCBI Accession Number
NP_055101
Uniprot Accession Number
P62166
Species
Human
AA Sequence
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