Recombinant human MINA protein
MINA is an oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. This protein is involved in the demethylation of trimethylated 'Lys-9' on histone H3 (H3K9me3), leading to an increase in ribosomal RNA expression. It also catalyzes the hydroxylation of 60S ribosomal protein L27a on 'His-39'. MINA may play an important role in cell growth and survival. It may be involved in ribosome biogenesis, most likely during the assembly process of pre-ribosomal particles. Recombinant human MINA protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
MYC induced nuclear antigen, FLJ14393, MDIG, MINA53, NO52
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
54.9 kDa (485aa)
Additionnal Information
References & Citations
Strausberg, R.L., et al. (2002) Proc. Natl. Acad. Sci. u.S.A. 99 (26), 16899-16903
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
AAH14928
Uniprot Accession Number
Q8IUF8
Species
Human
AA Sequence
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