Recombinant human KCNMB3 protein

The KCNMB3 is one of a family of four auxiliary beta subunits found in the mammalian genome that associate with Slo1 alpha subunits and regulate BK channel function. In humans, the KCNMB3 gene contains four N-terminal alternative exons that produce four functionally distinct beta3 subunits, beta3a-d. Three variants, beta3a-c, exhibit kinetically distinct inactivation behaviors. Recombinant human KCNMB3 fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Calcium-activated potassium channel subunit beta-3 isoform d, BKBETA3, HBETA3, KCNMB2, KCNMBL, SLOBETA3

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

16.8 kDa (149aa)

Additionnal Information

KCNMB3, calcium-activated potassium channel subunit beta-3 isoform d, BKBETA3, HBETA3, KCNMB2, KCNMBL, SLOBETA3, ATGP2801-10 µg, ATGP2801-20 µg, ATGP2801-50 µg, ATGP2801-100 µg, ATGP2801-250 µg, ATGP2801-500 µg, ATGP2801-1 mg, ATGP2801-10, ATGP2801-20, ATGP2801-50, ATGP2801-100, ATGP2801-250, ATGP2801-500, ATGP2801-1

References & Citations

Lee, u.S, et al. (2009) J. Physiol. (Lond.) 587 (PT 7), 1481-1498; ; Zeng, X., et al. (2008) J. Gen. Physiol. 132 (1), 115-129

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% glycerol

Scientific Category

Neuroscience

NCBI Accession Number

NP_055222

Uniprot Accession Number

Q9NPA1

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSKPFMLSI QREESTCTAI HTDIMDDWLD CAFTCGVHCH GQGKYPCLQV FVNLSHPGQK ALLHYNEEAV QINPKCFYTP KCHQDRNDLL NSALDIKEFF DHKNGTPFSC FYSPASQSED VILIKKYDQ