Recombinant human GNAQ protein
GNAQ is a guanine nucleotide-binding protein. GNAQ, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2. Recombinant human GNAQ protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Guanine nucleotide-binding protein G (q) subunit alpha, CMC1, G-ALPHA-q, GAQ, SWS
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
44.5 kDa (382aa)
Additionnal Information
References & Citations
Mudhar, H.S, et al. (2013) Br J Ophthalmol 97 (7), 924-928; ; Chishiki, K., et al. (2013) Biochem. Biophys. Res. Commun. 435 (3), 414-419
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% glycerol
Scientific Category
Cardiovascular
NCBI Accession Number
NP_002063
Uniprot Accession Number
P50148
Species
Human
AA Sequence
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