Recombinant human PDE6H protein

PDE6H is the inhibitory (or gamma) subunit of the cone-specific cGMP phosphodiesterase, which is a tetramer composed of two catalytic chains (alpha and beta), and two inhibitory chains (gamma) . It is specifically expressed in the retina, and is involved in the transmission and amplification of the visual signal. Mutations in this gene are associated with retinal cone dystrophy type 3A (RCD3A) . Recombinant human PDE6H protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Retinal cone rhodopsin-sensitive cGMP 3'5'-cyclic phosphodiesterase subunit gamma, Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma, ACHM6, RCD3

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 80% by SDS-PAGE

Molecular Weight

11.5 kDa (106aa) confirmed by MALDI-TOF

Additionnal Information

PDE6H, Retinal cone rhodopsin-sensitive cGMP 3'5'-cyclic phosphodiesterase subunit gamma, Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma, ACHM6, RCD3, ATGP2785-10 µg, ATGP2785-20 µg, ATGP2785-50 µg, ATGP2785-100 µg, ATGP2785-250 µg, ATGP2785-500 µg, ATGP2785-1 mg, ATGP2785-10, ATGP2785-20, ATGP2785-50, ATGP2785-100, ATGP2785-250, ATGP2785-500, ATGP2785-1