Recombinant human Serpin D1/Heparin cofactor II protein

SERIND1 is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. This protein contains five exons and four introns. It shares homology with antithrombin III and other members of the alpha 1-antitrypsin superfamily. Mutations in this gene are associated with heparin cofactor II deficiency. Recombinant human SERIND1 protein, fused to His-tag at N-terminus, was expressed in E. coli

Product Specifications

Product Name Alternative

Heparin cofactor 2 precursor, D22S673, HC2, HCF2, HCII, HLS2, LS2, THPH10

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

53.3 kDa (465aa)

Additionnal Information

Serpin D1, Heparin cofactor II, Heparin cofactor 2 precursor, D22S673, HC2, HCF2, HCII, HLS2, LS2, THPH10, ATGP2765-10 µg, ATGP2765-20 µg, ATGP2765-50 µg, ATGP2765-100 µg, ATGP2765-250 µg, ATGP2765-500 µg, ATGP2765-1 mg, ATGP2765-10, ATGP2765-20, ATGP2765-50, ATGP2765-100, ATGP2765-250, ATGP2765-500, ATGP2765-1

References & Citations

Van Deerlin V.M.D., Tollefsen D.M. (1991) J. Biol. Chem. 266:20223-20231.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M urea

Scientific Category

Cardiovascular

NCBI Accession Number

NP_000176

Uniprot Accession Number

P05546

Species

Human

AA Sequence

DFHKENT VTNDWIPEGE EDDDYLDLEK IFSEDDDYID IVDSLSVSPT DSDVSAGNIL QLFHGKSRIQ RLNILNAKFA FNLYRVLKDQ VNTFDNIFIA PVGISTAMGM ISLGLKGETH EQVHSILHFK DFVNASSKYE ITTIHNLFRK LTHRLFRRNF GYTLRSVNDL YIQKQFPILL DFKTKVREYY FAEAQIADFS DPAFISKTNN HIMKLTKGLI KDALENIDPA TQMMILNCIY FKGSWVNKFP VEMTHNHNFR LNEREVVKVS MMQTKGNFLA ANDQELDCDI LQLEYVGGIS MLIVVPHKMS GMKTLEAQLT PRVVERWQKS MTNRTREVLL PKFKLEKNYN LVESLKLMGI RMLFDKNGNM AGISDQRIAI DLFKHQGTIT VNEEGTQATT VTTVGFMPLS TQVRFTVDRP FLFLIYEHRT SCLLFMGRVA NPSRS