Recombinant human Serpin D1/Heparin cofactor II protein
SERIND1 is a serine proteinase inhibitor which rapidly inhibits thrombin in the presence of dermatan sulfate or heparin. This protein contains five exons and four introns. It shares homology with antithrombin III and other members of the alpha 1-antitrypsin superfamily. Mutations in this gene are associated with heparin cofactor II deficiency. Recombinant human SERIND1 protein, fused to His-tag at N-terminus, was expressed in E. coli
Product Specifications
Product Name Alternative
Heparin cofactor 2 precursor, D22S673, HC2, HCF2, HCII, HLS2, LS2, THPH10
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
53.3 kDa (465aa)
Additionnal Information
References & Citations
Van Deerlin V.M.D., Tollefsen D.M. (1991) J. Biol. Chem. 266:20223-20231.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M urea
Scientific Category
Cardiovascular
NCBI Accession Number
NP_000176
Uniprot Accession Number
P05546
Species
Human
AA Sequence
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