Recombinant human PD-L2/B7-DC protein

Programmed cell death 1 ligand 2, also known as PDCD1LG2, is involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production. Recombinant human PDCD1LG2 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Programmed cell death 1 ligand 2, B7DC, bA574F11.2, Btdc, CD273, PD-L2, PDCD1L2, PDL2

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

22.8 kDa (204aa)

Additionnal Information

PD-L2, B7-DC, Programmed cell death 1 ligand 2, B7DC, bA574F11.2, Btdc, CD273, PD-L2, PDCD1L2, PDL2, ATGP2757-10 µg, ATGP2757-20 µg, ATGP2757-50 µg, ATGP2757-100 µg, ATGP2757-250 µg, ATGP2757-500 µg, ATGP2757-1 mg, ATGP2757-10, ATGP2757-20, ATGP2757-50, ATGP2757-100, ATGP2757-250, ATGP2757-500, ATGP2757-1

References & Citations

Latchman Y., et al. (2001) Nat. Immunol. 2:261-268; ; Tseng S.-Y., et al. (2001) J. Exp. Med. 193:839-846;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Scientific Category

Immunology

NCBI Accession Number

NP_079515

Uniprot Accession Number

Q9BQ51

Species

Human

AA Sequence

LFTVTVP KELYIIEHGS NVTLECNFDT GSHVNLGAIT ASLQKVENDT SPHRERATLL EEQLPLGKAS FHIPQVQVRD EGQYQCIIIY GVAWDYKYLT LKVKASYRKI NTHILKVPET DEVELTCQAT GYPLAEVSWP NVSVPANTSH SRTPEGLYQV TSVLRLKPPP GRNFSCVFWN THVR