Recombinant human BMP-8b protein

The bone morphogenetic proteins (BMPs) are a family of secreted signaling molecules that can induce ectopic bone growth. Many BMPs are part of the transforming growth factor-beta (TGFB) superfamily. BMPs were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. Based on its expression early in embryogenesis, the BMP encoded by this gene has a proposed role in early development. In addition, the fact that this BMP is closely related to BMP5 and BMP7 has led to speculation of possible bone inductive activity. Recombinant human BMP8B protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Bone morphogenetic protein 8B, BMP8, OP2, Osteogenic protein 2

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

18.1 kDa (162aa)

Additionnal Information

BMP8b, Bone morphogenetic protein 8B, BMP8, OP2, ATGP2743-10 µg, ATGP2743-20 µg, ATGP2743-50 µg, ATGP2743-100 µg, ATGP2743-250 µg, ATGP2743-500 µg, ATGP2743-1 mg, ATGP2743-10, ATGP2743-20, ATGP2743-50, ATGP2743-100, ATGP2743-250, ATGP2743-500, ATGP2743-1

References & Citations

Oezkaynak E., et al. (1992) J. Biol. Chem. 267:25220-25227; ; Gregory S.G., et al. (2006) Nature. 441:315-321;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Scientific Category

Hormones & Cytokines

NCBI Accession Number

NP_001711

Uniprot Accession Number

P34820

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSAVRPLRR RQPKKSNELP QANRLPGIFD DVHGSHGRQV CRRHELYVSF QDLGWLDWVI APQGYSAYYC EGECSFPLDS CMNATNHAIL QSLVHLMMPD AVPKACCAPT KLSATSVLYY DSSNNVILRK HRNMVVKACG CH