Recombinant human GCHFR protein
GTP cyclohydrolase I feedback regulatory protein (GCHFR) binds to and mediates tetrahydrobiopterin inhibition of GTP cyclohydrolase I. The regulatory protein, GCHFR, consists of a homodimer. It is postulated that GCHFR may play a role in regulating phenylalanine metabolism in the liver and in the production of biogenic amine neurotransmitters and nitric oxide. Recombinant human GCHFR protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
GTP cyclohydrolase I feedback regulatory protein, GFRP, HsT16933, P35
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 95% by SDS-PAGE
Molecular Weight
12.1 kDa (107aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Chavan B., et al. (2006) J. Invest. Dermatol. 126:2481-2489; ; Swick L., et al. (2006) J. Neurochem. 97:1447-1455
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 40% glycerol, 1mM DTT
Scientific Category
Metabolism
NCBI Accession Number
NP_005249
Uniprot Accession Number
P30047
Species
Human
AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMPYLLIS TQIRMEVGPT MVGDEQSDPE LMQHLGASKR RALGNNFYEY YVDDPPRIVL DKLERRGFRV LSMTGVGQTL VWCLHKE
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