Recombinant human SP-D protein
SFTPD, as known as Surfactant pulmonary-associated protein D, is a member of the collectin family of C-type lectins that is synthesized in many tissues including respiratory epithelial cells in the lung, and contains one C-type lectin domain and one collagen-like domain. It is humoral molecules of the innate immune system, and is considered a functional candidate in chronic periodontitis. Besides it is involved in the development of acute and chronic inflammation of the lung. Several human lung diseases are characterized by decreased levels of bronchoalveolar SFTPD. Recombinant human SFTPD protein, fused to His-tag at N-terminus, was expressed in E. coli
Product Specifications
Product Name Alternative
Pulmonary surfactant-associated protein D precursor, COLEC7, PSP-D, SFTP4, SP-D
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
18.9 kDa (175aa)
Additionnal Information
References & Citations
Leth-Larsen R. et al. (2005) J Immunol. 174 : 1532-1538.; ; Hartl D. et al. (2006) Eur J Clin Invest. 36:423-435.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.4M urea
Scientific Category
Immunology
NCBI Accession Number
NP_003010.4
Uniprot Accession Number
P35247
Species
Human
AA Sequence
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