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Recombinant human SSX2 protein

SSX2 belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneous humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. The encoded hybrid proteins are likely responsible for transforming activity. Alternative splicing of this gene results in multiple transcript variants. Recombinant human SSX2, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Synovial sarcoma X breakpoint 2B, Synovial sarcoma, X breakpoint 2B, Cancer/testis antigen family 5, member 2b, CT5.2b

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

0.25 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

24.0 kDa (210aa)

Additionnal Information

SSX2, Synovial sarcoma X breakpoint 2B, Synovial sarcoma, X breakpoint 2B, Cancer/testis antigen family 5, member 2b, CT5.2b, ATGP2727-10 µg, ATGP2727-20 µg, ATGP2727-50 µg, ATGP2727-100 µg, ATGP2727-250 µg, ATGP2727-500 µg, ATGP2727-1 mg, ATGP2727-10, ATGP2727-20, ATGP2727-50, ATGP2727-100, ATGP2727-250, ATGP2727-500, ATGP2727-1

References & Citations

Neumann F, et al. (2013) Cancer Immunol Immunother, PMID 23619976.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M urea

Scientific Category

Epigenomics (Transcription & Translation)

NCBI Accession Number

NP_001157889

Uniprot Accession Number

Q16385

Species

Human

AA Sequence

MNGDDAFA RRPTVGAQIP EKIQKAFDDI AKYFSKEEWE KMKASEKIFY VYMKRKYEAM TKLGFKATLP PFMCNKRAED FQGNDLDNDP NRGNQVERPQ MTFGRLQGIS PKIMPKKPAE EGNDSEEVPE ASGPQNDGKE LCPPGKPTTS EKIHERSGPK RGEHAWTHRL RERKQLVIYE EISDPEEDDE

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