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Recombinant human STRADA protein

STE20-related kinase adapter protein alpha isoform 5, also known as STRADA, is a member of STE-20 like kinase family are known to stimulate MAPK pathways by directly activating MAPKKK. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. STRADA-LKB1 interaction results in phosphorylation of STRADA and enhanced autophosphorylation of LKB1. Recombinant human STRADA protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

STE20-related kinase adapter protein alpha isoform 5, LYK5, NY-BR-96, PMSE, Stlk, STRAD

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

37 kDa (337aa)

Additionnal Information

STRADA, STE20-related kinase adapter protein alpha isoform 5, LYK5, NY-BR-96, PMSE, Stlk, STRAD, ATGP2722-10 µg, ATGP2722-20 µg, ATGP2722-50 µg, ATGP2722-100 µg, ATGP2722-250 µg, ATGP2722-500 µg, ATGP2722-1 mg, ATGP2722-10, ATGP2722-20, ATGP2722-50, ATGP2722-100, ATGP2722-250, ATGP2722-500, ATGP2722-1

References & Citations

Avizienyte E., et al. (1998) Cancer Res. 58: 2087-2090.; ; Baas A F., et al. (2003) EMBO J. 22: 3062-3072.

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Scientific Category

Cell Cycle

NCBI Accession Number

NP_001159441

Uniprot Accession Number

Q7RTN6

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSMSFLVSK PERIRTNDAS SESIASFSKQ EVMSSFLPEG GCYELLTVIG KGFEDLMTVN LARYKPTGEY VTVRRINLEA CSNEMVTFLQ GELHVSKLFN HPNIVPYRAT FIADNELWVV TSFMAYGSAK DLICTHFMDG MNELAIAYIL QGVLKALDYI HHMGYVHRSV KASHILISVD GKVYLSGLRS NLSMISHGQR QRVVHDFPKY SVKVLPWLSP EVLQQNLQGY DAKSDIYSVG ITACELANGH VPFKDMPATQ MLLEKLNGTV PCLLDTSTIP AEELTMSPSR SVANSGLSDS LTTSTPRPSN GPVPAPS

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