Recombinant human STRADA protein
STE20-related kinase adapter protein alpha isoform 5, also known as STRADA, is a member of STE-20 like kinase family are known to stimulate MAPK pathways by directly activating MAPKKK. It functions as an upstream activator of LKB1 and also directs the sub-cellular localization of LKB1 by anchoring it in the cytoplasm. STRADA-LKB1 interaction results in phosphorylation of STRADA and enhanced autophosphorylation of LKB1. Recombinant human STRADA protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
STE20-related kinase adapter protein alpha isoform 5, LYK5, NY-BR-96, PMSE, Stlk, STRAD
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
37 kDa (337aa)
Additionnal Information
References & Citations
Avizienyte E., et al. (1998) Cancer Res. 58: 2087-2090.; ; Baas A F., et al. (2003) EMBO J. 22: 3062-3072.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
Scientific Category
Cell Cycle
NCBI Accession Number
NP_001159441
Uniprot Accession Number
Q7RTN6
Species
Human
AA Sequence
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