Recombinant human MLLT11 protein
Protein AF1q, also known as MLLT11, belongs to the Mixed-Lineage Leukemia (MLL) protein family. It is located on chromosome 11q23. MLLT11 plays a role in leukemogenesis and, specifically, the progression of acute monocytic leukemia (AML) . Also, expressed in embryonic brain cortex, MLLT11 is upregulated during neuronal differentiation and is thought to play a role in the development of the central nervous system. Recombinant human MLLT11 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Protein AF1q, AF1Q, RP11-316M1.10
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 80% by SDS-PAGE
Molecular Weight
12.4 kDa (113aa)
Additionnal Information
References & Citations
Chang X Z., et al. (2008) Breast cancer Res Treat. 111: 65-78.; ; Tse W., et al. (1995) Blood. 85: 650-656.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
Scientific Category
Other
NCBI Accession Number
NP_006809
Uniprot Accession Number
Q13015
Species
Human
AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSMRDPVSS QYSSFLFWRM PIPELDLSEL EGLGLSDTAT YKVKDSSVGK MIGQATAADQ EKNPEGDGLL EYSTFNFWRA PIASIHSFEL DLL
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