Recombinant Rat DYRK1A protein
DYRK1A is a member of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. This member contains a nuclear targeting signal sequence, a protein kinase domain, a leucine zipper motif, and a highly conservative 13-consecutive-histidin6e repeat. It catalyzes its autophosphorylation on serine/threonine and tyrosine residues. It may play a significant role in a signaling pathway regulating cell proliferation and may be involved in brain development. Recombinant rat DYRK1A protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Dual-specificity tyrosine- (Y) -phosphorylation regulated kinase 1A, Dual Specificity Yak1-related kinase, Dyrk; PSK47
Expression System
E.coli
Antigen Species
Rat
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 80% by SDS-PAGE
Molecular Weight
39.4 kDa (343aa)
Additionnal Information
References & Citations
Pryor A., Tung L. et al. (2004) . Nucleic Acids Res. 32:1857-1865
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M urea
Scientific Category
Neuroscience
NCBI Accession Number
NP_036923
Uniprot Accession Number
Q63470
Species
Rat
AA Sequence
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