Recombinant human ZCCHC12 protein

ZCCHC12 belongs to the ZCCHC12 family and contains 1 CCHC-type zinc finger. This protein is a transcriptional coactivator in the bone morphogenetic protein (BMP) -signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic-neuron-specific gene expression. Recombinant human ZCCHC12 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Znc finger CCHC domain-containing protein 12, PNMA7A, SIZN, SIZN1

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

47.8 kDa (425aa)

Additionnal Information

ZCCHC12, Znc finger CCHC domain-containing protein 12, PNMA7A, SIZN, SIZN1, ATGP2704-10 µg, ATGP2704-20 µg, ATGP2704-50 µg, ATGP2704-100 µg, ATGP2704-250 µg, ATGP2704-500 µg, ATGP2704-1 mg, ATGP2704-10, ATGP2704-20, ATGP2704-50, ATGP2704-100, ATGP2704-250, ATGP2704-500, ATGP2704-1

References & Citations

Li, Q.L, et al. (2012) Med. Oncol. 29 (3), 1409-1417; ; Cho, G., et al. (2009) J. Biol. Chem. 284 (29), 19592-19600

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% glycerol

Scientific Category

Epigenomics (Transcription & Translation)

NCBI Accession Number

NP_776159

Uniprot Accession Number

Q6PEW1

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSMASIIAR VGNSRRLNAP LPPWAHSMLR SLGRSLGPIM ASMADRNMKL FSGRVVPAQG EETFENWLTQ VNGVLPDWNM SEEEKLKRLM KTLRGPAREV MRVLQATNPN LSVADFLRAM KLVFGESESS VTAHGKFFNT LQAQGEKASL YVIRLEVQLQ NAIQAGIIAE KDANRTRLQQ LLLGGELSRD LRLRLKDFLR MYANEQERLP NFLELIRMVR EEEDWDDAFI KRKRPKRSES MVERAVSPVA FQGSPPIVIG SADCNVIEID DTLDDSDEDV ILVESQDPPL PSWGAPPLRD RARPQDEVLV IDSPHNSRAQ FPSTSGGSGY KNNGPGEMRR ARKRKHTIRC SYCGEEGHSK ETCDNESDKA QVFENLIITL QELTHTEMER SRVAPGEYND FSEPL