Recombinant human TARBP2 protein

TARBP2 is a component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. This protein contains 3 DRBM (double-stranded RNA-binding) domains. It may also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. TARBP2 binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. Recombinant human TARBP2 protein was expressed in E. coli.

Product Specifications

Product Name Alternative

TAR RNA binding protein 2 isoform b, LOQS, TRBP, TRBP1, TRBP2

Expression System

E.coli

Antigen Species

Human

Tag

Non-Tagged

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

36.9 kDa (345aa)

Additionnal Information

TARBP2, TAR RNA binding protein 2 isoform b, LOQS, TRBP, TRBP1, TRBP2, ATGP2702-10 µg, ATGP2702-20 µg, ATGP2702-50 µg, ATGP2702-100 µg, ATGP2702-250 µg, ATGP2702-500 µg, ATGP2702-1 mg, ATGP2702-10, ATGP2702-20, ATGP2702-50, ATGP2702-100, ATGP2702-250, ATGP2702-500, ATGP2702-1

References & Citations

Dorin D., et al (2003) . J. Biol. Chem. 278:4440-4448; ; Gregory R.I., et al (2005) . Cell 123:631-640;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.4M urea

Scientific Category

Epigenomics (Transcription & Translation)

NCBI Accession Number

NP_004169

Uniprot Accession Number

Q15633

Species

Human

AA Sequence

MLAANPGKTP ISLLQEYGTR IGKTPVYDLL KAEGQAHQPN FTFRVTVGDT SCTGQGPSKK AAKHKAAEVA LKHLKGGSML EPALEDSSSF SPLDSSLPED IPVFTAAAAA TPVPSVVLTR SPPMELQPPV SPQQSECNPV GALQELVVQK GWRLPEYTVT QESGPAHRKE FTMTCRVERF IEIGSGTSKK LAKRNAAAKM LLRVHTVPLD ARDGNEVEPD DDHFSIGVGS RLDGLRNRGP GCTWDSLRNS VGEKILSLRS CSLGSLGALG PACCRVLSEL SEEQAFHVSY LDIEELSLSG LCQCLVELST QPATVCHGSA TTREAARGEA ARRALQYLKI MAGSK