Recombinant human Uridine-cytidine kinase 1/UCK1 protein
UCK1 is a uridine-cytidine kinase that catalyzes the phosphorylation of uridine and cytidine to uridine monophosphate (uMP) and cytidine monophosphate (CMP) but not the phosphorylation of deoxyribonucleosides or purine ribonucleosides. This enzyme can also phosphorylate uridine and cytidine analogs and uses both ATP and GTP as a phosphate donor. Alternative splicing results in multiple splice variants encoding distinct isoforms. Recombinant human uCK1 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
URK1, Cytidine monophosphokinase 1, Uridine monophosphokinase 1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 80% by SDS-PAGE
Molecular Weight
17.5 kDa (152aa)
Additionnal Information
References & Citations
Van Rompay AR. et al. (1999) Mol. Pharmacol. 56:562-569.; ; Pearman AT. et al. (2001) Life Sci. 69:2361-2370.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.4M urea
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_113620.1
Uniprot Accession Number
Q9HA47
Species
Human
AA Sequence
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