Recombinant human MKPX/DUSP22 protein

DuSP22 belongs to the protein-tyrosine phosphatase family and contains 1 tyrosine-protein phosphatase domain. This protein activates the Jnk signaling pathway and dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) . Recombinant human DuSP22 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Dual specificity phosphatase 22, JKAP, JSP1, LMWDSP2, MKPX, VHX, JNK-stimulatory phosphatase-1, Low molecular weight dual specificity phosphatase 2, LMW-DSP2, Mitogen-activated protein kinase phosphatase x, MAP kinase phosphatase x, MKP-x

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

23.3 kDa (207aa)

Additionnal Information

DuSP22, Dual specificity phosphatase 22, JKAP, JSP1, LMWDSP2, MKPX, VHX, ATGP2684-10 µg, ATGP2684-20 µg, ATGP2684-50 µg, ATGP2684-100 µg, ATGP2684-250 µg, ATGP2684-500 µg, ATGP2684-1 mg, ATGP2684-10, ATGP2684-20, ATGP2684-50, ATGP2684-100, ATGP2684-250, ATGP2684-500, ATGP2684-1

References & Citations

Shen Y., et al. (2001) Proc. Natl. Acad. Sci. u.S.A. 98:13613-13618; ; Schwertassek u., et al. (2010) FEBS J. 277:2463-2473;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Scientific Category

Cell Cycle

NCBI Accession Number

NP_064570

Uniprot Accession Number

Q9NRW4

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSMGNGMNK ILPGLYIGNF KDARDAEQLS KNKVTHILSV HDSARPMLEG VKYLCIPAAD SPSQNLTRHF KESIKFIHEC RLRGESCLVH CLAGVSRSVT LVIAYIMTVT DFGWEDALHT VRAGRSCANP NVGFQRQLQE FEKHEVHQYR QWLKEEYGES PLQDAEEAKN ILAAPGILKF WAFLRRL