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Recombinant human MKPX/DUSP22 protein

DuSP22 belongs to the protein-tyrosine phosphatase family and contains 1 tyrosine-protein phosphatase domain. This protein activates the Jnk signaling pathway and dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK) . Recombinant human DuSP22 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Dual specificity phosphatase 22, JKAP, JSP1, LMWDSP2, MKPX, VHX, JNK-stimulatory phosphatase-1, Low molecular weight dual specificity phosphatase 2, LMW-DSP2, Mitogen-activated protein kinase phosphatase x, MAP kinase phosphatase x, MKP-x

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

23.3 kDa (207aa)

Additionnal Information

DuSP22, Dual specificity phosphatase 22, JKAP, JSP1, LMWDSP2, MKPX, VHX, ATGP2684-10 µg, ATGP2684-20 µg, ATGP2684-50 µg, ATGP2684-100 µg, ATGP2684-250 µg, ATGP2684-500 µg, ATGP2684-1 mg, ATGP2684-10, ATGP2684-20, ATGP2684-50, ATGP2684-100, ATGP2684-250, ATGP2684-500, ATGP2684-1

References & Citations

Shen Y., et al. (2001) Proc. Natl. Acad. Sci. u.S.A. 98:13613-13618; ; Schwertassek u., et al. (2010) FEBS J. 277:2463-2473;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Scientific Category

Cell Cycle

NCBI Accession Number

NP_064570

Uniprot Accession Number

Q9NRW4

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSMGNGMNK ILPGLYIGNF KDARDAEQLS KNKVTHILSV HDSARPMLEG VKYLCIPAAD SPSQNLTRHF KESIKFIHEC RLRGESCLVH CLAGVSRSVT LVIAYIMTVT DFGWEDALHT VRAGRSCANP NVGFQRQLQE FEKHEVHQYR QWLKEEYGES PLQDAEEAKN ILAAPGILKF WAFLRRL

Frequently Asked Questions

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