Recombinant human XAF1 protein
XAF1 is a protein which binds to and counteracts the inhibitory effect of a member of the IAP (inhibitor of apoptosis) protein family. IAP proteins bind to and inhibit caspases which are activated during apoptosis. The proportion of IAPs and proteins which interfere with their activity, such as the encoded protein, affect the progress of the apoptosis signaling pathway. Multiple transcript variants encoding different isoforms have been found for this gene. Recombinant human XAF1 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
XIAP associated factor 1 isoform 1, XIAP associated factor 1 isoform 1, BIRC4BP, HSXIAPAF1, XIAPAF1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
18.6 kDa (161aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Liston P., et al (2001) . Nat. Cell Biol. 3:128-133; ; Leaman D.W., et al (2002) . J. Biol. Chem. 277:28504-28511;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 30% glycerol 0.15M NaCl
Scientific Category
Apoptosis
NCBI Accession Number
NP_059993.2
Uniprot Accession Number
Q6GPH4
Species
Human
AA Sequence
MEGD FSVCRNCKRH VVSANFTLHE AYCLRFLVLC PECEEPVPKE TMEEHCKLEH QQVGCTMCQQ SMQKSSLEFH KANECQERPV ECKFCKLDMQ LSKLELHESY CGSRTELCQG CGQFIMHRML A
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