Recombinant human CD-M6PR protein
M6PR is a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. This protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. Recombinant human M6PR protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques..
Product Specifications
Product Name Alternative
Cation-dependent mannose-6-phosphate receptor isoform 1, CD-MPR, MPR 46, MPR-46, MPR46, SMPR
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
20.3 kDa (182aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Prabakaran T, Nielsen R., et al. (2012) PLoS One. 2012;7 (6) :e39975.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
Scientific Category
Immunology
NCBI Accession Number
NP_002346
Uniprot Accession Number
P20645
Species
Human
AA Sequence
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