Recombinant human BHMT2 protein
BHMT2 is involved in the regulation of homocysteine metabolism. Homocysteine is a sulfur-containing amino acid that plays a crucial role in methylation reactions. Transfer of the methyl group from betaine to homocysteine creates methionine, which donates the methyl group to methylate DNA, proteins, lipids, and other intracellular metabolites. BHMT2 is one of two methyl transferases that can catalyze the transfer of the methyl group from betaine to homocysteine. Recombinant human BHMT2 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
S-methylmethionine-homocysteine S-methyltransferase BHMT2 isoform 1, betaine-homocysteine S-methyltransferase 2, SMM-hcy methyltransferase
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
42.7 kDa (386aa)
Additionnal Information
References & Citations
Li F., et al. (2008) Mol Genet Metab. 94 (3) : 326-35.; ; Mostowaka A., et al. (2010) Eur Oral Sci. 118 (4) : 325-32.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
Scientific Category
Metabolism
NCBI Accession Number
NP_060084
Uniprot Accession Number
Q9H2M3
Species
Human
AA Sequence
Frequently Asked Questions
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