Recombinant human ICAM-2/CD102 protein

ICAM2 is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. Recombinant human ICAM2 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Intercellular adhesion molecule 2, CD102

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

24.8 kDa (225aa) confirmed by MALDI-TOF

Additionnal Information

ICAM2, Intercellular adhesion molecule 2, CD102, ATGP2645-10 µg, ATGP2645-20 µg, ATGP2645-50 µg, ATGP2645-100 µg, ATGP2645-250 µg, ATGP2645-500 µg, ATGP2645-1 mg, ATGP2645-10, ATGP2645-20, ATGP2645-50, ATGP2645-100, ATGP2645-250, ATGP2645-500, ATGP2645-1

References & Citations

Staunton D.E., et al. (1989) Nature. 339:61-64; ; Liu T., et al. (2005) J. Proteome Res. 4:2070-2080;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT

Scientific Category

Immunology

NCBI Accession Number

NP_001093259

Uniprot Accession Number

P13598

Species

Human

AA Sequence

SDEKVFE VHVRPKKLAV EPKGSLEVNC STTCNQPEVG GLETSLDKIL LDEQAQWKHY LVSNISHDTV LQCHFTCSGK QESMNSNVSV YQPPRQVILT LQPTLVAVGK SFTIECRVPT VEPLDSLTLF LFRGNETLHY ETFGKAAPAP QEATATFNST ADREDGHRNF SCLAVLDLMS RGGNIFHKHS APKMLEIYEP VSDSQ