Recombinant human CD5 protein

CD5 is a good immunohistochemical marker for T-cells, although not as sensitive as CD3. About 76% of T-cell neoplasms are reported to express CD5, and it is also found in chronic lymphocytic leukemia, hairy cell leukemia, and mantle cell lymphoma cells. It is commonly lost in cutaneous T-cell lymphoma, and its absence can be used as an indicator of malignancy in this condition. The absence of CD5 in T cell acute lymphoblastic leukemia, while relatively rare, is associated with a poor prognosis. Recombinant human CD5 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

T-cell surface glycoprotein CD5, LEu1, T1

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 80% by SDS-PAGE

Molecular Weight

41.0 kDa (371aa)

Additionnal Information

CD5, T-cell surface glycoprotein CD5, LEu1, T1, ATGP2639-10 µg, ATGP2639-20 µg, ATGP2639-50 µg, ATGP2639-100 µg, ATGP2639-250 µg, ATGP2639-500 µg, ATGP2639-1 mg, ATGP2639-10, ATGP2639-20, ATGP2639-50, ATGP2639-100, ATGP2639-250, ATGP2639-500, ATGP2639-1

References & Citations

Berland R. et al. (2002) Annu. Rev. Immunol. 20:253-300.; ; Osman N. et al. (1992) Eur. J. Immunol. 22:2995-3000.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.4M urea

Scientific Category

Immunology

NCBI Accession Number

NP_055022

Uniprot Accession Number

P06127

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSRLSWYDP DFQARLTRSN SKCQGQLEVY LKDGWHMVCS QSWGRSSKQW EDPSQASKVC QRLNCGVPLS LGPFLVTYTP QSSIICYGQL GSFSNCSHSR NDMCHSLGLT CLEPQKTTPP TTRPPPTTTP EPTAPPRLQL VAQSGGQHCA GVVEFYSGSL GGTISYEAQD KTQDLENFLC NNLQCGSFLK HLPETEAGRA QDPGEPREHQ PLPIQWKIQN SSCTSLEHCF RKIKPQKSGR VLALLCSGFQ PKVQSRLVGG SSICEGTVEV RQGAQWAALC DSSSARSSLR WEEVCREQQC GSVNSYRVLD AGDPTSRGLF CPHQKLSQCH ELWERNSYCK KVFVTCQDPN P