Recombinant human EPCR protein

PROCR is a receptor for activated protein C, a serine protease activated by and involved in the blood coagulation pathway. This protein is an N-glycosylated type I membrane protein that enhances the activation of protein C. Mutations in this gene have been associated with venous thromboembolism and myocardial infarction, as well as with late fetal loss during pregnancy. The encoded protein may also play a role in malarial infection and has been associated with cancer. Recombinant human PROCR protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Protein C receptor endothelial, Protein C receptor, endothelial, CCCA, CCD41, CD201, EPCR

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 80% by SDS-PAGE

Molecular Weight

24.4 kDa (216aa)

Additionnal Information

EPCR, Protein C receptor endothelial, Protein C receptor, endothelial, CCCA, CCD41, CD201, EPCR, ATGP2638-10 µg, ATGP2638-20 µg, ATGP2638-50 µg, ATGP2638-100 µg, ATGP2638-250 µg, ATGP2638-500 µg, ATGP2638-1 mg, ATGP2638-10, ATGP2638-20, ATGP2638-50, ATGP2638-100, ATGP2638-250, ATGP2638-500, ATGP2638-1

References & Citations

Fukudome K. et al. (1994) J Biol Chem. 269:26486-26491.; ; Van de Wouwer M. et al. (2005) Arterioscler. Thromb. Vasc. Biol. 24:1374-83.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.4M urea

Scientific Category

Cardiovascular

NCBI Accession Number

NP_006395

Uniprot Accession Number

Q9UNN8

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MGSSQDASDG LQRLHMLQIS YFRDPYHVWY QGNASLGGHL THVLEGPDTN TTIIQLQPLQ EPESWARTQS GLQSYLLQFH GLVRLVHQER TLAFPLTIRC FLGCELPPEG SRAHVFFEVA VNGSSFVSFR PERALWQADT QVTSGVVTFT LQQLNAYNRT RYELREFLED TCVQYVQKHI SAENTKGSQT SRSYTS