Recombinant human EXOSC8 protein
EXOSC8, also known as exosome component 8 and transcription factor 4, is a part of the exosome complex. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing Au-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. EXOSC8 binds to ARE-containing RNAs. Recombinant human EXOSC8 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography.
Product Specifications
Product Name Alternative
Exosome complex component RRP43, bA421P11.3, CIP3, EAP2, OIP2, p9, RP11- 421P11.3, RRP43, Rrp43p
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
32.4 kDa (299aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Andersen JS. et al. (2005) Nature. 433:77-83; ; Gerhard DS. et al. (2004) Gerhard DS. 14 : 2121-2127.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 50% glycerol 0.2M NaCl,1mM DTT
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_852480
Uniprot Accession Number
Q96B26
Species
Human
AA Sequence
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