Recombinant human H2AFZ protein
Histone H2A. Z, also known as H2AFZ, is a member of the histone H2A family. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4) . H2AFZ may be involved in the formation of constitutive heterochromatin and may be required for chromosome segregation during cell division. Also, H2AFZ is a variant Histone H2A which replaces conventional H2A in a subset of nucleosomes. Recombinant human H2AFZ protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Histone H2A.Z, H2A.z, H2A/z, H2AZ
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.25 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
15.9 kDa (151aa)
Additionnal Information
References & Citations
Rupp R A., et al. (2005) Cell. 123: 1178-1179.; ; Martin C., et al. (2005) Mol Cell Biol. 6:838-849.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
Scientific Category
Epigenomics (Transcription & Translation)
NCBI Accession Number
NP_002097
Uniprot Accession Number
P0C0S5
Species
Human
AA Sequence
MAGGKAG KDSGKAKTKA VSRSQRAGLQ FPVGRIHRHL KSRTTSHGRV GATAAVYSAA ILEYLTAEVL ELAGNASKDL KVKRITPRHL QLAIRGDEEL DSLIKATIAG GGVIPHIHKS LIGKKGQQKT V
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