Recombinant human APRIL/TNFSF13 protein

TNFSF13 is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. TNFSF13 and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Recombinant human TNFSF13 protein, fused to T7-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Tumor necrosis factor ligand superfamily member 13, A proliferation-inducing ligand, APRIL, TNF- and APOL-related leukocyte expressed ligand 2, TALL-2, TNF-related death ligand 1, TRDL-1, CD256, ZTNF2

Expression System

E.coli

Antigen Species

Human

Tag

T7-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by BCA assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

17.6 kDa (159aa)

Additionnal Information

APRIL, TNFSF13, ATGP2602-10 µg, ATGP2602-20 µg, ATGP2602-50 µg, ATGP2602-100 µg, ATGP2602-250 µg, ATGP2602-500 µg, ATGP2602-1 mg, ATGP2602-10, ATGP2602-20, ATGP2602-50, ATGP2602-100, ATGP2602-250, ATGP2602-500, ATGP2602-1

References & Citations

Pollard, R.P, et al. (2013) Ann. Rheum. Dis. 72 (1), 146-148; ; Notas, G., et al. (2012) J. Immunol. 189 (10), 4748-4758;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M Urea

Scientific Category

Cancer

NCBI Accession Number

NP_742085

Uniprot Accession Number

O75888

Species

Human

AA Sequence

AVLT QKQKKQHSVL HLVPINATSK DDSDVTEVMW QPALRRGRGL QAQGYGVRIQ DAGVYLLYSQ VLFQDVTFTM GQVVSREGQG RQETLFRCIR SMPSHPDRAY NSCYSAGVFH LHQGDILSVI IPRARAKLNL SPHGTFLGL