Recombinant human Haptoglobin/HP protein

HP, as known as haptoglobin, is processed to yield both alpha and beta chains, which subsequently combine as a tetramer to produce haptoglobin. In blood plasma, haptoglobin binds free hemoglobin (Hb) released from erythrocytes with high affinity and thereby inhibits its oxidative activity. The haptoglobin-hemoglobin complex will then be removed by the reticuloendothelial system (mostly the spleen) . Recombinant human HP protein, fused to His-tag at N-terminus, was expressed in E. coli

Product Specifications

Product Name Alternative

Haptoglobin isoform 2 preproprotein, Zonulin, BP, HP2ALPHA2, HPA1S

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 80% by SDS-PAGE

Molecular Weight

39.0 kDa (352aa)

Additionnal Information

HP, Haptoglobin isoform 2 preproprotein, Haptoglobin isoform 2 preproprotein, BP, HP2ALPHA2, HPA1S, ATGP2597-10 µg, ATGP2597-20 µg, ATGP2597-50 µg, ATGP2597-100 µg, ATGP2597-250 µg, ATGP2597-500 µg, ATGP2597-1 mg, ATGP2597-10, ATGP2597-20, ATGP2597-50, ATGP2597-100, ATGP2597-250, ATGP2597-500, ATGP2597-1

References & Citations

Dobryszycka W. et al. (1997) Eur J Clin Chem Clin Biochem. 35:647-654.; ; Wassell J. et al. (2000) Clin. Lab. 46:547-552.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.4M urea

Scientific Category

Cardiovascular

NCBI Accession Number

NP_001119574.1

Uniprot Accession Number

P00738

Species

Human

AA Sequence

VDSGNDV TDIADDGCPK PPEIAHGYVE HSVRYQCKNY YKLRTEGDGV YTLNNEKQWI NKAVGDKLPE CEAVCGKPKN PANPVQRILG GHLDAKGSFP WQAKMVSHHN LTTGATLINE QWLLTTAKNL FLNHSENATA KDIAPTLTLY VGKKQLVEIE KVVLHPNYSQ VDIGLIKLKQ KVSVNERVMP ICLPSKDYAE VGRVGYVSGW GRNANFKFTD HLKYVMLPVA DQDQCIRHYE GSTVPEKKTP KSPVGVQPIL NEHTFCAGMS KYQEDTCYGD AGSAFAVHDL EEDTWYATGI LSFDKSCAVA EYGVYVKVTS IQDWVQKTIA EN