Recombinant human DOK4 protein
DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of multimolecular signaling complexes. DOK4 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. This protein is putative link with downstream effectors of RET in neuronal differentiation. DOK4 may be involved in the regulation of the immune response induced by T-cells. Recombinant human DOK4 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Docking protein 4, Downstream of tyrosine kinase 4, FLJ10488, IRS-5, IRS5
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
39.4 kDa (349aa)
Additionnal Information
References & Citations
Hooker, E, et al. (2012) Biochem. Biophys. Res. Commun. 427 (1), 67-72; ; Gerard, A., et al. (2009) J. Immunol. 182 (12), 7681-7689;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M uREA, 10% glycerol
Scientific Category
Signal Transduction
NCBI Accession Number
NP_060580
Uniprot Accession Number
Q8TEW6
Species
Human
AA Sequence
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