Recombinant human STAMP2/STEAP4 protein

STEAP4 belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe (3+) to Fe (2+) and Cu (2+) to Cu (1+), using NAD (+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. Recombinant human STEAP4 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

Tumor necrosis factor alpha-induced protein 9, Tumor necrosis factor, Alpha-induced protein 9, DKFZp666D049, FLJ23153, STAMP2, TIARP, TNFAIP9, STEAP4 metalloreductase

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

1 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

20.6 kDa (188aa)

Additionnal Information

Alpha induced protein 9, Alpha-induced protein 9, DKFZp666D049, FLJ23153, STAMP 2, STAMP2, STAMP-2, STEAP4 metalloreductase, TIARP, TNFAIP 9, TNFAIP9, TNFAIP-9, Tumor necrosis factor, Tumor necrosis factor alpha induced protein 9, Tumor necrosis factor alpha-induced protein 9, ATGP2593-10 µg, ATGP2593-20 µg, ATGP2593-50 µg, ATGP2593-100 µg, ATGP2593-250 µg, ATGP2593-500 µg, ATGP2593-1 mg, ATGP2593-010, ATGP2593-020, ATGP2593-050, ATGP2593-100, ATGP2593-250, ATGP2593-500, ATGP2593-01M

References & Citations

Kim, H.Y, et al. (2012) Exp. Mol. Med. 44 (10), 622-632; ; Tanaka, Y., et al. (2012) Clin. Exp. Rheumatol. 30 (1), 99-102;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M UREA, 10% glycerol

Scientific Category

Cancer

NCBI Accession Number

NP_078912

Uniprot Accession Number

Q687X5

Species

Human

AA Sequence

MEKT CIDALPLTMN SSEKQETVCI FGTGDFGRSL GLKMLQCGYS VVFGSRNPQK TTLLPSGAEV LSYSEAAKKS GIIIIAIHRE HYDFLTELTE VLNGKILVDI SNNLKINQYP ESNAEYLAHL VPGAHVVKAF NTISAWALQS GALDASRQ