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Recombinant human VCC-1/CXCL17 protein

Chemokine (C-X-C motif) ligand 17, also known as CXCL17, is a small cytokine belonging to the CXC chemokine family. CXCL17 is a 119 amino acid secreted protein that plays a role in angiogenesis. CXCL17 is expressed in skeletal muscle, trachea, lung, intestine and stomach, and is upregulated in duodenal mucosa of patients with acute cholera, as well as breast tumors. CXCL17 is considered a housekeeping chemokine for the movement of immature dendritic cells and non activated blood monocytes into tissues, and is thought to be involved in the innate immune response. Recombinant human CXCL17 protein, fused to His-tag at N-terminus, was expressed in E. coli.

Product Specifications

Product Name Alternative

VEGF coregulated chemokine 1, VCC-1, VCC1, uNQ473, MGC138300, DMC, Dendritic cell and monocyte chemokine-like protein, Dcip1, C-X-C motif chemokine ligand 17, Chemokine (C-X-C motif) ligand 17, 6-Cys CXCL17

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE, Denatured

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 85% by SDS-PAGE

Molecular Weight

13.7 kDa (119aa)

Additionnal Information

CXCL17, VCC1, Chemokine (C-X-C motif) ligand 17, Chemokine (C-X-C motif) ligand 17, Dcip1, DMC, MGC138300, uNQ473, VCC-1, VCC1, ATGP2591-10 µg, ATGP2591-20 µg, ATGP2591-50 µg, ATGP2591-100 µg, ATGP2591-250 µg, ATGP2591-500 µg, ATGP2591-1 mg, ATGP2591-10, ATGP2591-20, ATGP2591-50, ATGP2591-100, ATGP2591-250, ATGP2591-500, ATGP2591-1

References & Citations

Weinstein E J., et al. (2006) Biochem Biophys Res Commun. 350:74-81.; ; Hiraoka N., et al. (2011) Gastroenterology. 140:310-321.;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol

Scientific Category

Hormones & Cytokines

NCBI Accession Number

NP_940879

Uniprot Accession Number

Q6UXB2

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MSSLNPGVAR GHRDRGQASR RWLQEGGQEC ECKDWFLRAP RRKFMTVSGL PKKQCPCDHF KGNVKKTRHQ RHHRKPNKHS RACQQFLKQC QLRSFALPL

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