Recombinant human VCC-1/CXCL17 protein
Chemokine (C-X-C motif) ligand 17, also known as CXCL17, is a small cytokine belonging to the CXC chemokine family. CXCL17 is a 119 amino acid secreted protein that plays a role in angiogenesis. CXCL17 is expressed in skeletal muscle, trachea, lung, intestine and stomach, and is upregulated in duodenal mucosa of patients with acute cholera, as well as breast tumors. CXCL17 is considered a housekeeping chemokine for the movement of immature dendritic cells and non activated blood monocytes into tissues, and is thought to be involved in the innate immune response. Recombinant human CXCL17 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
13.7 kDa (119aa)
Additionnal Information
References & Citations
Weinstein E J., et al. (2006) Biochem Biophys Res Commun. 350:74-81.; ; Hiraoka N., et al. (2011) Gastroenterology. 140:310-321.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
Scientific Category
Hormones & Cytokines
NCBI Accession Number
NP_940879
Uniprot Accession Number
Q6UXB2
Species
Human
AA Sequence
MGSSHHHHHH SSGLVPRGSH MSSLNPGVAR GHRDRGQASR RWLQEGGQEC ECKDWFLRAP RRKFMTVSGL PKKQCPCDHF KGNVKKTRHQ RHHRKPNKHS RACQQFLKQC QLRSFALPL
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