Recombinant human TGFBRAP1 protein
TGFBRAP1 plays a role in the TGF-beta/activin signaling pathway. It associates with inactive heteromeric TGF-beta and activin receptor complexes, mainly through the type II receptor, and is released upon activation of signaling. It may recruit SMAD4 to the vicinity of the receptor complex and facilitate its interaction with receptor-regulated Smads, such as SMAD2. Recombinant human TGFBRAP1 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Transforming growth factor beta receptor associated protein 1, Transforming growth factor, beta receptor associated protein 1, TRAP-1, TRAP1
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 80% by SDS-PAGE
Molecular Weight
33 kDa (296aa)
Additionnal Information
References & Citations
Felts SJ, Owen BA, et al. (2000) . J Biol Chem. 275 (5) :3305-12.; ; Simmons AD, Musy MM, et al. (1999) . Hum Mol Genet. 8 (12) :2155-64.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.4M urea, 10% glycerol
Scientific Category
Cancer
NCBI Accession Number
NP_004248
Uniprot Accession Number
Q8WUH2
Species
Human
AA Sequence
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