Recombinant human NKp30/NCR3 protein
NCR3, also known as NKP30, is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene. Recombinant human NCR3 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.
Product Specifications
Product Name Alternative
Natural cytotoxicity triggering receptor 3, 1C7, CD337, LY117, MALS, NKp30
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
15.3 kDa (141aa) confirmed by MALDI-TOF
Additionnal Information
References & Citations
Venter J.C., et al. (2001) Science. 291:1304-1351; ; Gerhard D.S., et al. (2004) Genome Res. 14:2121-2127;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT
Scientific Category
Stem Cell
NCBI Accession Number
NP_001138939
Uniprot Accession Number
O14931
Species
Human
AA Sequence
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