Recombinant human NKp30/NCR3 protein

NCR3, also known as NKP30, is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene. Recombinant human NCR3 protein, fused to His-tag at N-terminus, was expressed in E. coli and purified by using conventional chromatography techniques.

Product Specifications

Product Name Alternative

Natural cytotoxicity triggering receptor 3, 1C7, CD337, LY117, MALS, NKp30

Expression System

E.coli

Antigen Species

Human

Tag

His-Tag

Applications

SDS-PAGE

Concentration

0.5 mg/mL (determined by Bradford assay)

Purity

> 90% by SDS-PAGE

Molecular Weight

15.3 kDa (141aa) confirmed by MALDI-TOF

Additionnal Information

NKp30, NCR3, Natural cytotoxicity triggering receptor 3, 1C7, CD337, LY117, MALS, NKp30, ATGP2583-10 µg, ATGP2583-20 µg, ATGP2583-50 µg, ATGP2583-100 µg, ATGP2583-250 µg, ATGP2583-500 µg, ATGP2583-1 mg, ATGP2583-10, ATGP2583-20, ATGP2583-50, ATGP2583-100, ATGP2583-250, ATGP2583-500, ATGP2583-1

References & Citations

Venter J.C., et al. (2001) Science. 291:1304-1351; ; Gerhard D.S., et al. (2004) Genome Res. 14:2121-2127;

Storage Conditions

Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.

Formulation

Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 0.15M NaCl, 10% glycerol, 1mM DTT

Scientific Category

Stem Cell

NCBI Accession Number

NP_001138939

Uniprot Accession Number

O14931

Species

Human

AA Sequence

MGSSHHHHHH SSGLVPRGSH MLWVSQPPEI RTLEGSSAFL PCSFNASQGR LAIGSVTWFR DEVVPGKEVR NGTPEFRGRL APLASSRFLH DHQAELHIRD VRGHDASIYV CRVEVLGLGV GTGNGTRLVV EKEHPQLGAG T