Recombinant human IL-28A/IFNL2 protein
IFNL2, also known as Interleukin 28A (IL28A), is a cytokine distantly related to type I interferons and the IL-10 family. Interleukin 28A (IL28A), Interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA) . Recombinant human IFNL2 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Interferon lambda 2, IFN-lambda-2, Cytokine Zcyto20, Interleukin-28A, IL-28A, ZCYTO20
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
0.5 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
22.1 kDa (198aa)
Additionnal Information
References & Citations
Sheppard P., et al. (2003) Nat. Immunol. 4:63-68.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M urea
Scientific Category
Hormones & Cytokines
NCBI Accession Number
NP_742150
Uniprot Accession Number
Q8IZJ0
Species
Human
AA Sequence
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