Recombinant human Kallikrein 15/KLK15 protein
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. KLK15 is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. In prostate cancer, it has increased expression, which indicates its possible use as a diagnostic or prognostic marker for prostate cancer. KLK15 contains multiple polyadenylation sites and alternative splicing results in multiple transcript variants encoding distinct isoforms. Recombinant human KLK15 protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Kallikrein-15, kallikrein related peptidase 15, ACO protease, HSRNASPH, prostinogen
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 90% by SDS-PAGE
Molecular Weight
28.2 kDa (258aa)
Additionnal Information
References & Citations
Yousef GM, Scorilas A, et al. (2001) J Biol Chem 276 (1) : 53-61.
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol, 0.4M urea
Scientific Category
Cancer
NCBI Accession Number
NP_059979
Uniprot Accession Number
Q9H2R5
Species
Human
AA Sequence
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