Recombinant human CRHBP protein
Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. Recombinant human CRHBP protein, fused to His-tag at N-terminus, was expressed in E. coli.
Product Specifications
Product Name Alternative
Corticotropin-releasing factor-binding protein precursor, corticotropin-releasing factor-binding protein precursor, CRF-BP, CRFBP
Expression System
E.coli
Antigen Species
Human
Tag
His-Tag
Applications
SDS-PAGE, Denatured
Concentration
1 mg/mL (determined by Bradford assay)
Purity
> 85% by SDS-PAGE
Molecular Weight
36.1 kDa (324aa)
Additionnal Information
References & Citations
Behan DP. et al. (1993) Genomics. 16:63-68.; ; Westphal NJ. et al. (2006) Front. Biosc.. 11: 1878-91.;
Storage Conditions
Can be stored at 2°C to 8°C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
Formulation
Liquid in. 20 mM Tris-HCl buffer (pH 8.0) containing 10% glycerol 0.4M urea
Scientific Category
Signal Transduction
NCBI Accession Number
NP_001873
Uniprot Accession Number
P24387
Species
Human
AA Sequence
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